Research Interests

Cardiovascular Biology and Diseases

Biomarker for Diagnostics & Therapeutics

Research Summary

The goal of Kim’s lab at Pusan National University School of Medicine is to develop the preventive/therapeutic tools for cardiovascular diseases. Therefore, the research has mainly focused on identifying new molecules involved in the regulation of blood circulation. Especially, Kim’s lab has focused on unveiling the mechanism for the development of atherosclerosis/vascular restenosis to develop preventive/therapeutic methods for occlusive cardiovascular diseases as well as finding key regulatory factors for angiogenesis. At present, both basic and clinical research teams are being innervated to develop the novel therapeutic approaches for cardiovascular diseases.

Selected publication

1. Jang EJ et al., HMGB1 enhances AGE-mediated VSMC proliferation via an increase in 5-LO-linked RAGE expression. Vascular Pharmacology, 118-119 (2019) 106559.

2. Lee SJ et al., SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes. Experimental & Molecular Medicine, 51:47, 2019.Park SY et al., Multitarget-based cotreatment with cilostazol and celecoxib synergistically suppresses collagen-induced arthritis in mice enhancing interleukin-10 expression. International Immunopharmacology, 73:461-470, 2019.

3. Kim EJ et al., HMGB1 increases IL-1B production in vascular smooth muscle cells via NLRP3 inflammasome. Frontiers in Physiology, doi:10.3389/fphys. 2018.00313, 2018.

4. Baek SE et al., BLTR1 in monocytes emerges as a therapeutic target for vascular inflammation with a subsequent intimal hyperplasia in a murine wire-injured femoral artery. Frontiers in Immunology, doi:10.3389/fimmu. 2018.01938, 2018.

5. HMGB1 increases IL-1B production in vascular smooth muscle cells via NLRP3 inflammasome. Frontiers in Physiology, doi: 10.3389/fphys.2018.00313, 2018.

6. Baek SE et al., 5-Lipoxygenase in monocytes emerges as a therapeutic target for intimal hyperplasia in a murine wire-injured femoral artery. Biochim Biophys Acta, 1863(9): 2210-2219, 2017.

7. Park et al., SIRT1/AMP-activated protein kinase alpha signaling enhances macrophage polarization to an anti-inflammatory phenotype in rheumatoid arthritis. Frontiers in Immunology, doi:10.3389/fimmu. 2017.01135, 2017.

8. Alpha-iso-cubebene inhibits PDGF-induced vascular smooth muscle proliferation by suppressing osteopontin expression. PLoS One, 12(1):e0170699, 2017.