Research Interest

Systems Toxicology and Informatics

Mucosal Immunology and Microbiome

Research Summary

1. Gut Exposome Bioinformatics: The forefront of environmental and dietary exposure is the mucosal barrier and is a key recognition area of the mucosal immune system. Integrative analysis and prediction of interactions between the host mucosa and biochemical environments such as microbiota, dietary metabolites, and microbial toxins through the computational network science.

2. Mucosal Network: As a cellular sensor for mucosal environmental stress, ribosomes are a key cellular network sentinel in the integrated stress response (ISR). In particular, the ribosomal ISR network was identified in the informatics-based Adverse Outcome Pathway during the mucosal immune responses and diseases in response to microorganisms and chemical exposures in the mucosal barrier.

Selected publication

1. Park, SH., Kim, J., and Moon, Y. Caveolar communication with xenobiotic-stalled ribosomes compromises gut barrier integrity. Communications Biology (2020). 3 (1): 270.

2. Kim, KH., Lee, SJ., Kim, J., and Moon, Y. Dynamic Malignant Wave of Ribosome-insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit. iScience (2020). 23(5): 101076.

3. Yu M, Kim J, Ahn JH, Moon Y. Nononcogenic restoration of the intestinal barrier by E. coli-delivered human EGF. (2019). Journal of Clinical Investigation (JCI)/Insight 4 (16). e125166.

4. Park SH, Kim J, Yu M, Park JH, Kim YS, Moon Y. Epithelial Cholesterol Deficiency Attenuates Human Antigen R-linked Pro-inflammatory Stimulation via an SREBP2-linked Circuit (2016). J Biol Chem. 291(47):24641.

5. Oh CK, Park SH, Kim, J., Moon Y. Non-mutagenic Suppression of Enterocyte Ferroportin-1 by Chemical Ribosomal Inactivation via p38 MAPK-mediated Regulation: Evidences for Environmental Hemochromatosis (2016). J Biol Chem. 291(38):19858.

6. Choi, HJ, Do KH, Park, JH, Kim, J, Park SH, Yu, M, Moon Y. Early Epithelial Restitution by Nonsteroidal Anti-Inflammatory Drug?Activated Gene 1 Counteracts Intestinal Ulcerative Injuries (2016). J. of Immunology. 197(4):1415.

7. Do KH, Park SH, Kim J, Yu M, Moon Y. Ribosome Inactivation Leads to Attenuation of Intestinal Polymeric Ig Receptor Expression via Differential Regulation of Human Antigen R (2016). J. of Immunology. 197(3):847.

8. Oh CK, Lee SJ, Park SH, Moon Y. Acquisition of Chemoresistance and Other Malignancy-related Features of Colorectal Cancer Cells Are Incremented by Ribosome-inactivating Stress (2016). J Biol Chem. 291(19):10173.

9. Park SH, Choi HJ, Do KH, Kim J, Moon Y. Activating Transcription Factor 3-mediated Chemo- intervention with Cancer Chemokines in a Non-Canonical Pathway under Endoplasmic Reticulum Stress (2014) J Biol Chem. 289(39):27118.

10. Park, SH, Do, KH, Choi, HJ, Kim, J, Kim, K, Park, J, Oh, CG, and Moon, Y. Novel Regulatory Action of Ribosomal Inactivation on Epithelial Nod2-linked Pro-inflammatory Signals in Two Convergent ATF3- associated Pathways. (2013). Journal of Immunology 191(10), 5170-5180.

11. Choi, HJ, Kim, J., Do, KH, Park, S., and Moon, Y. Enteropathogenic Escherichia coli-induced macrophage inhibitory cytokine 1 mediates cancer cell survival: An in vitro implication of infection-linked tumor dissemination (2013). Oncogene 32 (41), 4960-4969.

12. Do, KH, Choi, HJ, Kim, J, Park, SH, Kim, KH, and Moon. Y. Suppressor of cytokine signaling 3 regulates B cell activating factor in human enterocytes under ribosomal stress. (2013). J. of Immunology 190(12), 6501.