Research Interest

Transcriptional modulation of FGF21 under various stress conditions

Characterization of adaptive response against metabolic stress

Research Summary

The major interest of the Song lab is to identify central and peripheral component of metabolic stress response. Recent research indicates prolonged chronic stress can contribute to metabolic syndrome. By combing proteomic and secretomic analysis after metabolic stressor treated conditions like high fat, phosphate or salt diet, we want to find tissue-derived factors, which affect to metabolic syndrome. Especially, we are trying to understand how metabolic hormone FGF21 (Fibroblast growth factor 21) expression is differently regulated. Also we will confirm metabolic output in global or liver specific FGF21 knockout mice under various pathophysiologic conditions. Furthermore, we have interest in evaluating

Selected publication

1. Kim DH, Ham MH, Lee SY, Shin MJ, Kim YE, Song P, Suh DS, Kim JH. CD166 Promotes the Cancer Stem-like Properties of Primary Epithelial Ovarian Cancer Cells. BMB Rep. 2020 Aug 26:5051

2. Kim DH*, Song P*, Han JH, Hur J. Ex vivo expansion of regulatory T cell and T helper 2 cells using a hematosphere culture. Immunobiology. 2020 Feb 22:151918.

3. Ha M, Kim J, Park SM, Hong CM, Han ME, Song P, Kang CD, Lee D, Kim YH, Hur J, Oh SO. Prognostic Role of Zinc Finger Homeobox 4 in Ovarian Serous Cystadenocarcinoma. Genet Test Mol Biomarkers. 2020 Mar;24(3):145-149

4. Song P., Kwon Y., Joo, JY., Kim, DG., and Yoon, J.H. Secretomics to Discover Regulators in Diseases. Int J Mol Sci. 2019 Aug 9;20(16)

5. Jung, S.Y., Yun, J., Kim, S.J., Kang, S., Kim, D.Y., Kim, Y.J., Park, J.H., Jang, W.B., Ji, S.T., Ha, J.S., Van, L.T.H., Giang, T.T., Rethineswaran, V.K., Song, P*., and Kown S.M*. Basic helix-loop-helix transcription factor Twist1 is a novel regulator of anterior gradient protein 2 homolog (AGR2)in breast cancer. Biochemical and Biophysical Research Communications. 2019 Aug 13;516(1):149-156

6. Song P., and Kim JH. Benefits of Angiotensin Receptor Blockade: Preventing Smooth Muscle Cell Senescence and Beyond. Korean Circ J. 2019 Jul;49(7):627-628

7. Song, P., Zechner, C., Hernandez, G., C?novas, J., Xie, Y., Sondhi, V., Wagner, M., Stadlbauer, V., Horvath, A., Leber, B., Hu, M.C., Moe, O.W., Mangelsdorf, D.J., and Kliewer, S.A. The hormone FGF21 stimulates water drinking in response to ketogenic diet and alcohol. Cell Metabolism. 2018 Jun 5;27(6):1338-1347.

8. Song, P*., Schumann, G*., Liu, C*., O’Reilly, P.F*., Gao, H*., et al. KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. PNAS. 2016 Dec 13;113(50):14372-14377. (*Co-first authors).

9. Lee, C.S., Ghim, J., Song, P., Suh, P.G., and Ryu, S.H. Loss of phospholipase D2 impairs VEGF-induced angiogenesis. BMB Rep. 2016 Mar;49(3):191-6.

10. Talukdar*, S., Owen, B.M*., Song, P., Hernandez, G., Zhang, Y., Zhou, Y., Scott, W.T., Paratala, B., Turner, T., Smith, A., Bernardo, B., M?ller C.P., Tang H., Mangelsdorf D.J., Goodwin B., and Kliewer S.A. FGF21 Regulates Sweet and Alcohol Preference. Cell Metabolism. 2016 Feb 9;23(2):344-9.