Research Interest

Convergence midicine

Rejuvenation

Stem cells and their Niche

Angiogenesis & Inflammation

Immunology

Research Summary

The ultimate goal of Hur lab (Lab for rejuvenation) is to make conceptual advances and ground-breaking discoveries in regenerative medicine through basic and stem cell-based convergence research. Many of the functions of cells and organs in our body decrease markedly with disease and age. Therefore, our research goal is first to restore normal functioning organ and second, to reveal the mechanism that makes them young again (rejuvenation). To this end, our research has focused on unveiling the interactions between stem cells and their niche (microenvironment), regulatory mechanism of angiogenesis and inflammation in malfunctioning organs (including cancer).

Selected publication

1. PPAR-δ agonist affects Adipo-chondrogenic differentiation of human Mesenchymal Stem Cells through the expression of PPAR-γ. Kim DH, Kim DH, Heck BE, Shaffer M, Yoo KH, Hur J. Regenerative Therapy. 2020 Dec;15:103-111.

2. A natural supplement formula reduces anti-oxidative stress and enhances osteochondrogenic differentiation potential in mesenchymal stem cells. Kim DH, Kim DH, Bruce E. Heck. Michael Shaffer. Hur J*. Yoo KH*. J Clin Biochem Nutr. 2020 May;66(3):206-212. * co-corresponding author

3. Prognostic Role of Zinc Finger Homeobox 4 in Ovarian Serous Cystadenocarcinoma. Ha M, Kim J, Park SM, Hong CM, Han ME, Song P, Kang CD, Lee D, Kim YH, Hur J*, Oh SO*. Genet Test Mol Biomarkers. 2020 Mar;24(3):145-149. * co-corresponding author.

4. Ex vivo expansion of regulatory T cell and T helper 2 cells using a hematosphere culture. Kim DH, Song P, Han JH, Hur J. Immunobiology. 2020 Feb 22:151918.

5. Rabbit palatum-derived mesenchymal progenitor cells tri-lineage differentiation on 2D substrates and 3D printed constructs. Kim DH, Kim BY, Kim DH, Hur J,* Baek CH.* J Appl Biomater Funct Mater. 2019 Jul;17(3). * co-corresponding author.

6. KAI1(CD82)-DARC(CD234) axis in the stem cell niche. Jin Hur et. al. Cell Cycle. 2016 Aug 2;15(15):1945-7.

7. CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages. Jin Hur*, Jae-Il Choi* et. al. Cell Stem Cell. 2016 Apr 7;18(4):508?21. * co-first authors

8. Priming mobilized peripheral blood mononuclear cells with the “activated platelet supernatant” enhances the efficacy of cell therapy for myocardial infarction of rats. Kang J*, Hur J*, Kang JA*. Cardiovascular Therapeutics. 2016 Aug;34(4):245-53. * co-first authors

9. M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARβ/δ Activation in Tumor Myeloid Cells, Leading to Tumor Progression. Park J*, Lee SE*, Hur J*, et. al. Cell Rep. 2015 Mar 10;10(9):1614-25. * co-first authors.

10. Human podoplanin-positive monocytes and platelets enhance lymphangiogenesis through the activation of the podoplanin/CLEC-2 axis. Hur J*, Jang JH*, Oh IY*. et.al. Mol Ther. 2014 Aug;22(8):1518-29. * co-first authors.

11. Erythropoietin priming improves the vasculogenic potential of G-CSF mobilized human peripheral blood mononuclear cells. Kang J*, Yun JY*, Hur J*, et. al. Cardiovasc Res. 2014 Oct 1;104(1):171-82. * co-first authors.

12. Activated platelet supernatant can augment the angiogenic potential of human peripheral blood stem cells mobilized from bone marrow by G-CSF. Kang J*, Hur J*, Kang JA*, et. al. J Mol Cell Cardiol. 2014 Oct;75:64-75. * co-first authors

13. Highly angiogenic CXCR4(+)CD31(+) monocyte subset derived from 3D culture of human peripheral blood. Hur J*, Choi JI*, Yun JY*, et. al. Biomaterials. 2013 Mar;34(8):1929-41. * co-first authors

14. New method to differentiate human peripheral blood monocytes into insulin producing cells: Human hematosphere culture. Hur J*, Yang JM*, et. al. Biochem Biophys Res Commun. 2012 Feb 24;418(4):765-9. * co-first authors

15. Human peripheral blood-born hematosphere as a niche for hematopoietic stem cell expansion. Hur J*, Park J*, Lee SE*, et. al. Cell Res. 2011 Jun;21(6):987-90. * co-first authors.

16. Identification of a Novel Role of T cells in Postnatal Vasculogenesis : Characterization of Endothelial Progenitor Cell Colonies. Jin Hur*, Han-Mo Yang*, Chang-Hwan Yoon*, et. al. Circulation. 2007 Oct 9;116(15):1671-82.

17. Akt Is a Key Modulator of Endothelial Progenitor Cell Trafficking in Ischemic Muscle. J. Hur*, C.-H. Yoon*, et. al. Stem Cells. 2007 July; 25(7):1769-78.

18. Intercellular Adhesion Molecule-1 Is Upregulated in Ischemic Muscle, Which Mediates Trafficking of Endothelial Progenitor Cells. Chang-Hwan Yoon*, Jin Hur*, et. al. Arterioscler Thromb Vasc Biol. 2006 May;26(5):1066-72. * co-first authors.

19. Synergistic Neovascularization by Mixed Transplantation of Early Endothelial Progenitor Cells and Late Outgrowth Endothelial Cells. Chang-Hwan Yoon*, Jin Hur*, et. al. Circulation. 2005 Sep 13;112(11):1618-27. * co-first authors.

20. Augmentation of Therapeutic Angiogenesis Using Genetically Modified Human Endothelial Progenitor Cells with Altered Glycogen Synthase Kinase-3 Activity. Jin-Ho Choi*, Jin Hur*, et. al. J. Biol. Chem. 2004 Nov 19;272(47):49430-8. * co-first authors.

Characterization of Two Types of Endothelial Progenitor Cells and Their Different Contributions to Neovasculogenesis. Jin Hur*, Chang-Hwan Yoon*, et. al. Arterioscler Throm